RESEARCH

The Foundation for Craniofacial Surgery supports a full-time research laboratory located in the Regenerative Bioengineering and Repair (REBAR) Lab at UCLA. Dr. Jarrahy’s research team has presented the results of their basic science and clinical research projects at multiple prestigious international and national research meetings over the years, and Dr. Jarrahy has published many peer-reviewed scientific journal articles that have helped advance the field of craniofacial surgery through innovation and ingenuity.

Recent Publications:

Jarrahy R. Controversies in the management of neonatal micrognathia: to distract or not to distract, that is the question. J Craniofac Surg 2012 Jan;23(1):243-9.

Jarrahy R, Bradley J. Reply: The Role of Three-Dimensional Computed Tomography in Evaluating Facial Trauma. Plast Reconstr Surg. 2012 Feb;129(2):355e-356e.

Lakin G, Jarrahy R. Commentary on “Nonsyndromic Craniosynostosis: Current Treatment Options.” J Craniofac Surg. 2012 Nov;23(7 Suppl 1):2066-7.

Thaller S, Jarrahy R. The Kawamoto epilogue: a prologue for craniofacial surgery. J Craniofac Surg. 2012 Nov;23(7 Suppl 1):1999.

Tanna N, Im DD, Azhar H, Roostaeian J, Lesavoy MA, Bradley JP, Jarrahy R. Inferior Turbinoplasty During Cosmetic Rhinoplasty: Techniques and Trends. Ann Plast Surg. 2012 Dec 13. [Epub ahead of print]

Im DD, Paskhover B, Staffenberg DA, Jarrahy R. Current Management of Microtia: A National Survey. Aesthetic Plast Surg. 2013 Apr;37(2):402-8.

 Vardanian A, Kusnezov N, Im D, Lee J, Jarrahy R. Social media use and impact on plastic surgery practice. Plast Reconstr Surg. 2013 May;131(5):1184-93.

Hokugo A, Sorice S, Buck A, Lee J, Li A, Zuk P, Jarrahy R. In vitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells. Plast Recon Surg. 2013 Jul;132(1):70e-80e.

Raposo-Amaral CE, Tong A, Denadai R, Yalom A, Raposo-Amaral CA, Bertola D, Li A, Jarrahy R. A subcranial LeFort III advancement with distraction osteogenesis as a clinical strategy to approach pycnodysostosis with midface retrusion and exorbitism. J Craniofac Surg. 2013 Jul;24(4):1327-30.

Hokugo A, Sorice S, Parhami F, Yalom A, Li A, Zuk P, Jarrahy R. A novel oxysterol promotes bone regeneration in rabbit cranial bone defects. J Tissue Eng Regen Med. 2013 Aug 29 [Epub ahead of print]

Li A, Yoon A, Vardanian A, Nguyen P, Gordon C, Jarrahy R. Patient Rankings: Why patient feedback should affect our delivery of care, and influence on pay is still premature. Bull Am Coll Surg. 2013 Nov;98(11):22-3.

Kaufman MR, Elkwood A, Collichio AR, Cece J, Jarrahy R, Willekes LJ, Rose MI, Brown D. Functional restoration of diaphragmatic paralysis: an evaluation of phrenic nerve surgery. Ann Thor Surg. 2014 Jan;97(1):260-6.

Hokugo A; Saito T; Li A; Sato K; Tabata Y; Jarrahy R. Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel . Biomaterials. 2014 Jul;35(21):5565-71. Epub (ahead of print) 2014 Apr 14. PMID: 24731715

Yalom A, Hokugo A, Zuk P, Jarrahy R. In vitro osteoinductive effects of hydroxycholesterol on human adipose-derived stem cells are mediated though the Hedgehog signaling pathway. (Accepted, Plast Recon Surg April 2014, in press)

Hokugo A, Segovia A, Li A, Zuk P, Jarrahy R. The chemotactic Smart Scaffold for vascularization and tissue regeneration. (Accepted, Plast Recon Surg July 2014, in press)

Yoo S, Pineles SL, Jarrahy R, Velez FG. Ophthalmic manifestations of cherubism (Accepted, J Amer Acad Ped Opth Strab Aug 2014, in press)

Cece J, Aboharb F, Rezzadeh KS, Brown D, Jarrahy R, Kaufman MR. Klippel-Feil syndrome and unilateral diaphragmatic paralysis. (Accepted, Eplasty. Jan 2015, in press)

Kaufman MR, Elkwood AI, Aboharb F, Cece J, Brown D, Rezzadeh KS, Jarrahy R. Diaphragmatic reinnervation in ventilator dependent patients with cervical spinal cord injury and concomitant phrenic nerve lesions using simultaneous nerve transfers and implantable neurostimulators. (Accepted, J Reconstr Microsurg Feb 2015, in press)

Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. Natural Killer Cells Differentiate Human Adipose-derived Stem Cells and Modulate their Adipogenic Potential. (Accepted, Plast Recon Surg. March 2015, in press)

Li A, Hokugo A, Segovia L, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Parhami F, Stappenbeck F, Jarrahy R. Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone healing model. Accepted, J Tissue Eng Regen Med. April 2015, in press.)

Rezzadeh, K, Nojan M, Buck A, Li A, Vardanian A, Crisera C, Festekjian J, Jarrahy R. The use of negative pressure wound therapy in severe open lower extremity fractures: indentifying the association between length of therapy and surgical outcomes. complications of tissue transfer related to length of therapy. (Accepted, J Surg Res. June 2015, in press.)

Recent Abstracts Presented:

Segovia LA, Hokugo A, Li A, Yalom A, Jarrahy R. Tissue Engineered Peripheral Nerve Repair Using a Nanofiber Scaffold. American College of Surgeons Annual Clinical Congress. San Francisco, CA, October 26-30, 2014.

Segovia LA, Hokugo A, Li A, Yalom A, Zuk P, Jarrahy R. Adipose-Derived Stem Cells Treated with Novel Oxysterol Analogues Demonstrate Osteoinductive Activity. American College of Surgeons Annual Clinical Congress. San Francisco, CA, October 26-30, 2014.

Taub B, Jarrahy R. Surgical Anthropology:Sculpting a New Paradigm. American Anthropological Association 113th Annual Meeting. Washington, DC, December 3-7, 2014.

Yaghoubian A, Rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. Peripheral nerve regeneration using novel bioengineered peptide amphiphile nanofibers: in vivo studies. American Society for Peripheral Nerve, 2015 Annual Meeting. January 21-27, 2015. Paradise Island, Bahamas.

Rezzadeh KA, Segovia LA, Hokugo Jarrahy R. Negative Pressure Wound Therapy in Severe Open Fractures: Complications Related to Length of Therapy. 10th Annual Academic Surgical Congress. Las Vegas, NV, February 3-5, 2015.

Rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. Oxysterol Analogue Promotes in vitro and in vivo Bone Regeneration. Northwest Society of Plastic Surgeons: 53rd Annual Scientific Meeting. February 14-18, 2015. Kona, HI.

rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. A Novel Mobile Technology Platform Allows for HIPAA-Sensitive Perioperative Messaging and Improves Physician-Patient Communication.  Northwest Society of Plastic Surgeons: 53rd Annual Scientific Meeting. February 14-18, 2015. Kona, HI.

Rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. The Use of Negative Pressure Wound Therapy in Severe Open Lower Extremity Fractures: The Association Between Length of Therapy and Surgical Complications. Northwest Society of Plastic Surgeons: 53rd Annual Scientific Meeting. February 14-18, 2015. Kona, HI.

Rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. The Use of a Novel Mobile Technology Platform to Facilitate Instantaneous HIPAA-Sensitive Perioperative Messaging Improves Patient Care and Physician-Patient Communication. American Cleft Palate-Craniofacial Association: 72nd Annual Meeting. April 20-25, 2015. Palm Springs, CA. 

Segovia LA, Rezzadeh KS, Hokugo A, Jarrahy R. A New Osteogenic Agent, Oxysterol, Induces Bone Repair in Rabbit Craniofacial Defects. American Cleft Palate-Craniofacial Association: 72nd Annual Meeting. April 20-25, 2015. Palm Springs, CA.  

Segovia LA, Rezzadeh KS, Hokugo A, Jarrahy R. A New Concept for Craniofacial Repair Using Chemotactic Scaffolds. American Cleft Palate-Craniofacial Association: 72nd Annual Meeting. April 20-25, 2015. Palm Springs, CA.

Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. Natural Killer Cells Promote Differentiation Of Human Adipose-Derived Stem Cells in vitro. 60th Annual Meeting of the Plastic Surgery Research Council. May, 2015. Seattle, WA.

Rezzadeh KS, Segovia LA, Hokugo A, Jarrahy R. A Novel Analogue of Oxysterol Promotes in vitro and in vivo Bone Regeneration. 60th Annual Meeting of the Plastic Surgery Research Council. May 14-16, 2015. Seattle, WA.

Cece J, Aboharb F, Rezzadeh KS, Brown D, Jarrahy R, Kaufman MR. A Case of Klippel-Feil Syndrome and Unilateral Diaphragmatic Paralysis.” American Thoracic Society, 110th International Conference. May 15-20, 2015. Denver, CO. 

Kaufman MR, Elkwood AI, Aboharb F, Cece J, Brown D, Rezzadeh KS, Jarrahy R. Successful Reversal of Ventilator Dependency in Cervical Spinal Cord Injury with Concomitant Phrenic Nerve Lesions Using Simultaneous Nerve Transfers and Diaphragmatic Pacemakers. 110th International Conference. May 15-20, 2015. Denver, CO.

Legacy:

Perhaps most importantly, the research fellows we have trained continue to demonstrate a commitment to academic excellence that defines our research efforts. These fellows have followed on their successes in the lab with prestigious positions where they will complete their clinical training and prepare to become our future leaders in academic plastic surgery. 

Research Fellows Trained             Lab Year                 Current Position

Akishige Hokugo, DDS, PhD       2010-Present          REPBAR Lab Director, UCLA

Sarah Sorice, MD                          2010-2011             Plastic Surgery Resident, Stanford

Anisa Buck Yalom, MD                 2011-2012            Hand Surgery Fellow, U of Pennsylvania

James Lee, MD                              2011-2013            Plastic Surgery Resident, Cornell

Andrew Li, MD                             2012-2013            Plastic Surgery Resident, UCLA (2015-2018)

Andres Segovia, MD                      2013-2015            General Surgery Resident, Guatemala City

Kameron Rezzadeh, BS                  2014-2015            Plastic Surgery Resident, UCLA (2015-2021)

Situo Zhou, MS                             2014-2016            Plastic Surgery Resident, China

Zheyu Zhang, BS                           2014-2016            Yale Public Health/Management Masters

Reena Bakshi                                  2016-2017